Your skin also loses its elasticity. Our results showed that fucoxanthin treatment suppresses UVB-induced TNF-α and VEGF expression in corneal tissues. Any advice would be greatly appreciated. Disability compensation—monthly payment for diseases associated with Agent Orange exposure during military service. These may have their onset in childhood but sometimes later. The fundus may also have areas of yellow mottling temporal to the fovea suggestive of an orange peel surface. At the time of presentation, her best-corrected visual acuity was OD 20/30 and OS 20/25. University Privacy Statement For example, a person may look yellow because of liver problems, slightly blue because of breathing problems, bruised because of blood disorders, or pink or red because of skin problems or extra sensitivity to sunlight. Future installments will cover such topics as cataract surgery in the settings of other comorbidities, such as age-related macular edema, glaucoma, and diabetic retinopathy. Thus the condition described here may also be a digenic disorder in some individuals. J Invest Dermatol. There is no treatment for the connective tissue defect but individual problems such as subretinal neovascularization, hemorrhages, and vascular occlusions may respond to appropriate therapy. The examination is painless and safe. Five skin conditions associated with coronavirus have been identified by dermatologists, according to a new study. Special Considerations in Cataract Surgery is an occasional series on challenging situations in cataract surgery. Automatic detection of fruit skin defects is always one of the main tasks of post-harvest processing of citrus fruit. Agent Orange is a chemical defoliant that was sprayed by the U.S. during the Vietnam War to kill plants and clear land. The exposure to the Agent Orange and dioxin can damage people's cornea … Veterans who served in Vietnam, the Korean demilitarized zone or other areas where Agent Orange was sprayed may be eligible. When light enters through the cornea, it bends and refocuses the light to the retina, which begins translating the light into vision. Orange peel extracts can reduce melanin deposits, fade dark spots, and brighten your skin. It is smooth, clear and referred to as the window of the eye, because the cornea allows light to pass through to the eye. The sclera is opaque due to the irregularity of the Type I collagen fibers, as opposed to the near-uniform thickness and parallel arrangement of the corneal collagen. The impact on visual acuity and its prognosis has not been systematically studied. Symptoms include nausea, fever, and anemia. In adults, jaundice usually doesn't need to be treated. Some heterozygotes have minor manifestations of the disease but the full clinical picture is only seen in homozygotes. Several diseases of the urinary system (kidneys, ureters, bladder and urethra) can cause orange urine. ... Dermabrasion is used to treat uneven skin textures due to all of the following conditions EXCEPT: a) acne b) facial scars c) fine wrinkles d) sunken cheeks. The University of Arizona is an EEO/AA - M/W/D/V Employer. [Epub ahead of print]. Chronic lymphocytic leukemia is characterized by production of an excessive number of white blood cells. Multiple myeloma is a cancer caused by an overproduction of certain proteins from white blood cells. Leukemia is a cancer of the blood cells. At age 60, George was diagnosed with Stage 4 mantel cell lymphoma. However, it is a challenge to identify different types of defects simultaneously due to a high rate of unpredictability in texture and color of defects. The oral, rectal, and vaginal mucosa may also be involved. The ulcer may be central in the cornea or marginal, at the outer edge of the cornea. Wilson's disease is a genetic disorder in which excess copper builds up in the body. These frequently involve the central macula which is why central vision is primarily impacted and peripheral vision usually remains normal. A significant proportion of patients have atrophy of the RPE and outer retina, especially those with early onset and rapid progression of the disease. However, the skin changes are more widespread and involve trunk as well as limbs and flexural areas. Bergen AA. These tumors are relatively rare. Ron DeSantis to allow more teachers be … Another eye disease caused by the Agent Orange is an iritis, which also involves an inflammation in a person's iris. Acknowledgements and Rights | Admin | Login. Soft tissue sarcomas are a group of cancers in body tissues such as muscle, fat, blood and lymph vessels and connective tissues (that is, distinct from hard tissue such as bone or cartilage). Submitted by Angelica73 on Mon, 01/09/2017 - 19:16. Over time, this damages and weakens the heart muscle making it difficult for the heart to fill and pump blood to the rest of the body. Exposure to Agent Orange is associated with many diseases. The term "corneal disease" covers the variety of conditions that affect the cornea, the clear outer layer of the eye. Vision correction surgery, also called refractive and laser eye surgery, refers to any surgical procedure used to fix vision problems. Following is a list of the diseases and disorders presumed by the USDVA to be related to Agent Orange exposure and the symptoms associated with these diseases: AL amyloidosis is a rare disease caused when amyloid proteins are abnormally deposited in tissues or organs. J Eur Acad Dermatol Venereol. It is a curved, transparent structure with a radius of 7.8 mm. Mild forms may resemble teenage acne. Mild forms may resemble teenage acne. Symptoms are typically related to the brain and liver.Liver-related symptoms include vomiting, weakness, fluid build up in the abdomen, swelling of the legs, yellowish skin and itchiness.Brain-related symptoms include tremors, muscle stiffness, trouble speaking, personality changes, anxiety, and psychosis. Too much UV light damages the retina, lens or cornea. Plomp AS, Toonstra J, Bergen AA, van Dijk MR, de Jong PT. For more information about veteran health, including military exposures, diseases and conditions, treatments, wellness and more, go to www.publichealth.va.gov/index.asp. Retinitis pigmentosa has been diagnosed clinically and confirmed by ERG studies in some patients. GI bleeds require prompt and vigorous treatment and cardiac valves sometimes require repair. Visual Impairment in Pseudoxanthoma Elasticum: A Survey of 40 Patients. The cornea also helps to shield the eye from harmful matter, such as dust and germs. Chloracne is a rare skin eruption of blackheads, cysts and nodules, which has been linked directly to dioxin exposure. vitamin A. Antibiotic prophylaxis should be considered for patients with heart valve disease before undergoing procedures. Skin changes color usually because something is going on in the body. 2014 Apr 21. J Invest Dermatol. The cornea develops from both surface ectoderm and mesoderm. 2014 Apr 16. [Epub ahead of print]. Finger RP, Charbel Issa P, Hendig D, Scholl HP, Holz FG. Leukemia is a type of cancer that affects white blood cells. Ischemic heart disease is a common cause of congestive heart failure. (In chronic cases, effects appear much later.) The condition fades slowly after exposure. Angular cheilitis, also known as angular stomatitis and perlèche, causes swollen, red patches in the corners on the outside of your lips. Department of Ophthalmology and Vision Science ... yellow-orange. If you have symptoms of ectropion, you should seek medical attention. Chloracne is a rare skin eruption of blackheads, cysts and nodules, which has been linked directly to dioxin exposure. The USDVA presumes that 14 different diseases and disorders are related to Agent Orange exposure when diagnosed in “boots-on-the-ground” veterans and certain other veterans groups. Redundant skin can be surgically removed. This is an autosomal recessive disorder caused by mutations in the ABCC6 gene (16p13.1). He worked on all kinds of aircraft, including those used to dump the toxic herbicide Agent Orange over the jungles to expose enemy hiding places. Macular involvement is evident at a mean age of 44 years and the majority of patients are visually handicapped by the age of 52 years. Epub 2013 Apr 4. More than 40 years after the U.S. military used Agent Orange to defoliate the jungles of Vietnam, the health care bill is escalating for taxpayers. ORANGE COUNTY, Fla. – School board members with Orange County Public Schools drafted a letter asking Gov. To find the office nearest you, go to www.cacvso.org, click on “Contact Us,” and then click on “San Diego.”, Submitted by larry Sullivan on Mon, 02/05/2018 - 04:19, Submitted by Devon on Wed, 05/03/2017 - 06:20, Submitted by Tom Lemon on Tue, 01/10/2017 - 14:56. Coronary artery disease is frequently a symptom. If you were exposed to Agent Orange during your military service, you may qualify for VA disability benefits. About 2.7 million U.S. military personnel may have been exposed. Hodgkin’s disease : A type of lymphoma cancer involving abnormal cell growth in the lymph nodes. The skin has characteristic changes of several types due to defective elastin. The study was done on humans, and none of the subjects developed skin irritation ( 9 ). Three forms of specific skin disease occur in people with lupus, and it is possible to have lesions of multiple types. Gliem M, Muller PL, Birtel J, Hendig D, Holz FG, Charbel Issa P. Frequency, Phenotypic Characteristics and Progression of Atrophy Associated With a Diseased Bruch's Membrane in Pseudoxanthoma Elasticum. Special Considerations in Cataract Surgery is an occasional series on challenging situations in cataract surgery. While it is often considered benign, particularly in the elderly, evidence suggests that if may predictive of heart disease in younger people. Peripheral neuropathy is a condition of the peripheral nervous system, which consists of nerves outside the brain and spinal cord. Vanakker OM, Martin L, Gheduzzi D, Leroy BP, Loeys BL, Guerci VI, Matthys D, Terry SF, Coucke PJ, Pasquali-Ronchetti I, De Paepe A. Pseudoxanthoma elasticum-like phenotype with cutis laxa and multiple coagulation factor deficiency represents a separate genetic entity. The reaction is not confined to the site of contact and may result in systemic responses.ACD may be caused by industrial compounds (i.e. https://en.wikipedia.org/wiki/Monsanto Occlusive disease of the renal arteries can result in hypertension. See your doctor if you notice a new skin growth, a bothersome change in your skin, a change in the appearance or texture of a mole, or a sore that doesn't heal. How To Use: Dry and powder the orange peels. Cornea. Choroidal neovascularization should be treated. The cornea is the outermost layer of the eye. Cachexia is a condition in which you suffer from severe loss of weight. Minor cases may disappear altogether, but more severe cases may persist for years after the exposure. Twenty million gallons of Agent Orange were sprayed during the Vietnam War. ... What condition is the partial or complete loss of melanocytes from patches of skin which produces irregular white spots? Ophthalmic Genet. The latter are typically seen in the skin of the neck, in inguinal folds and in the popliteal and antecubital spaces. Changes to the cornea’s curvature can create mild to severe distortion, called astigmatism, and usually nearsightedness. Monthly Ranibizumab for Choroidal Neovascularizations Secondary to Angioid Streaks in Pseudoxanthoma Elasticum: A One-Year Prospective Study. Ischemic Heart Disease : A progressive condition in which the heart receives inadequate blood supply, resulting in chest pain and other complications. It is characterized by plasma cell tumors in bones in multiple parts of the body. Surviving spouses, dependent children and dependent parents of veterans who were exposed to Agent Orange or other herbicides during military service and died as the result of diseases related to the exposure may be eligible for survivors' benefits. In deciding claims for disability benefits due to Agent Orange exposure, the VA cannot simply disregard a claim because it is not on the list of Agent Orange diseases. They are generally asymptomatic and primarily of cosmetic importance. Cerebral aneurysms, vascular occlusions, and atherosclerotic plaques in the lower extremities have been reported in a few patients. Rare variant mutations in the ABCC6 gene may cause typical ocular changes without systemic manifestations. © 2019 The Arizona Board of Regents on behalf of The University of Arizona. The VA must take the further step of analyzing whether the disease in fact came from exposure to Agent Orange. The masc. They hypothesized that the poor results compared with those from the western literature were because these patients had more severe degree of disease due … Intermittent claudication can be incapacitating. Exposure to Agent Orange varied a great deal. People with this condition may at one time have had a heart attack, angina, or unstable angina—sometime with no previous symptoms. Getting orange hair colour after a bleaching session is very common. Orange or very dark urine may be caused by liver disease, and your doctor will probably begin your evaluation with a panel of blood tests known as liver function tests, or LFTs 1.The liver is the largest internal organ and performs a wide variety of functions that are essential to life. Urine that appears orange results from changes in the contents of the urine. However, in the PXE-like condition described here homozygous or compound heterozygous mutations in the GGCX (gamma-glutamyl carboxylase) gene (2p11.2) are responsible. Fuchs' dystrophy usually affects both eyes and can cause your vision to gradually worsen over years. Optic disc drusen are said to occur 20-50 times more frequently than in the general population and may be apparent before the appearance of angioid streaks. In type 2 diabetes mellitus, the body does not produce enough insulin or the body's cells ignore the insulin. Future installments will cover such topics as cataract surgery in the settings of other comorbidities, such as age-related macular edema, glaucoma, and diabetic retinopathy. Patients should avoid contact sports and activities requiring heavy lifting or straining. Respiratory cancers are cancers of the lung, larynx, trachea, and bronchus. Ultrastructurally the elastic fibers are more severely fragmented than those in classic PXE. There are no hard and fast rules regarding what constitutes “too much” beta-carotene in your diet. Prostate cancer is cancer of the prostate, a small gland in the male reproductive system. One thing you should know is that you need not go to a hair dresser for fixing your orange hair. The extremely dense innervation of the cornea means that corneal abrasions are typically very painful. Peau d'orange (French for "orange peel skin" or, more literally, "skin of an orange") describes anatomy with the appearance and dimpled texture resemble an orange peel. Eye damage. WASHINGTON — A group of lawmakers introduced legislation that would add nine more diseases to a list of conditions presumed to be caused by the chemical herbicide Agent Orange… Mild forms may resemble teenage acne. This can lead to glare, blurred or cloudy vision, and eye discomfort. First genetic analysis of atypical phenotype of pseudoxanthoma elasticum with ocular manifestations in the absence of characteristic skin lesions. Each day my face gets worse developing new breaks and depressions in top layer of skin. Hemorrhage or occlusion often results. The sun can also burn your eyes. In Fuchs' (fewks) dystrophy, fluid builds up in the clear layer (cornea) on the front of your eye, causing your cornea to swell and thicken. Usually, a skin biopsy is used to diagnose forms of cutaneous lupus, and various medications are available for treatment, including steroid ointme… Orssaud C, Roche O, Dufier JL, Germain DP. It is responsible for about 65 percent of focusing power for the eye. Kariminejad A, Bozorgmehr B, Najafi A, Khoshaeen A, Ghalandari M, Najmabadi H, Hasan Kariminejad M, Vanakker OM, Hosen MJ, Malfait F, Quaglino D, Florijn RJ, Bergen AA, Hennekam RC. Ectropion is when your lower eyelid turns or sags outward, away from your eye, exposing the surface of your inner eyelid. It is often lax and redundant with localized plaques of hyperkeratotic papules giving the typical 'plucked chicken' appearance. Monsanto had a big display at Disneyland in Tomorrow Land in the 1960's. Many Vietnam veterans and their survivors may be missing out on substantial payments they are entitled to receive as a result of exposure to Agent Orange, veterans’ advocates say.. Certain birth defects in the children of Vietnam veterans may also be the result of Agent Orange exposure. However, it is a challenge to identify different types of defects simultaneously due to a high rate of unpredictability in texture and color of defects. He died just 18 months later. The acute or sub-acute ("early-onset") form of peripheral neuropathy refers to symptoms occurring within weeks after exposure. Products derived from flowers and herbs have long been used for medicinal and culinary purposes. The images show the structure of the skin and the level of dryness very impressively. Around 15% to 25% of people with celiac suffer from dermatitis herpetiformis, a rash considered the skin manifestation of celiac disease. College of Medicine Along the inner surface of the cornea is a layer of cells called the endothelium. Corneal opacities are eye problems that can lead to scarring or clouding of the cornea, which decreases vision.. Parkinson's disease is a degenerative brain disorder that leads to shaking, stiffness, and difficulty with walking, balance, and coordination. To learn about your state and federal veterans benefits or how to file a claim, contact the San Diego County Veterans Service Office. "Poisoning the World" should be the company motto. Tears defend the cornea against bacteria, viruses, and fungi. J Invest Dermatol. What are differences in skin color due to? It was contaminated with dioxin, which is known to cause cancer and other conditions. Li Q, Grange DK, Armstrong NL, Whelan AJ, Hurley MY, Rishavy MA, Hallgren KW, Berkner KL, Schurgers LJ, Jiang Q, Uitto J. Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes. Neurological conditions that have been attributed to Agent Orange exposure include Parkinson’s disease―a condition that causes muscle stiffness, difficulty in movement and is characterized by postural tremors and instability. The eyelids may be swollen, and a white or gray round spot on the cornea could be visible with the naked eye if the ulcer is large. Furthermore, it is estimated that 2,000,000 people have suffered from illnesses caused by exposure and that half a million babies were born with birth defects due to the effects of Agent Orange. Exposure may have been possible through the eyes or through breaks in the skin, as well. 2006 Apr;126(4):704-5. Classic pseudoxanthoma elasticum is due to homozygous mutations in the ABCC6 (ATP-binding cassette subfamily C member 6) gene. The skin has characteristic changes of several types due to defective elastin. 2007 Mar;127(3):581-7. Corneal Abrasion. Symptoms can include: Angular cheilitis … Diabetes is a chronic disease that affects the body's ability to use blood sugar for energy. The disease can also cause swelling, scars on your cornea, and vision loss . [Epub ahead of print]. You will suffer from various health problems like high pressure, ulcers and hip fractures due to cachexia. The cornea is the most anterior structure of the eye and comprises one-sixth of the circumference of the globe. Non-Hodgkin's lymphoma is a type of cancer of the lymph glands and other lymphatic tissue, which are part of the body’s immune system that help to fight infection and disease. The U.S. Department of Veterans Affairs (USDVA) presumed that George’s disease was the result of his Agent Orange exposure 40 years earlier. Veterans with qualifying service in Vietnam or the Korean demilitarized zone are presumed to have been exposed to Agent Orange. It is often lax and redundant with localized plaques of hyperkeratotic papules giving the typical 'plucked chicken' appearance. If you have this condition, you were born with it, but you probably won’t have symptoms until your 30s or 40s. B-cells are a specific type of lymph cell that affect a body’s immune system. Many patients in addition have deficiencies in vitamin K-dependent clotting factors such as II, VII, IX, and X. Epistaxis, spontaneous gingival bleeding and severe vaginal hemorrhages may occur. May 2, 2013 (Sacramento)--U.S. Air Force veteran George Chappell was a fuels specialist in Vietnam. My family spent 10 years on Okinawa and have found out that that schools that I worked at and that they attended have unearthed 83 barrels of the chemical. Download PDF. about Pseudoxanthoma Elasticum-Like Disease, Retinitis Pigmentosa, Cutis Laxa and Pseudoxanthoma Elasticum-Like Skin Manifestations Associated with GGCX Mutations, Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes, Pseudoxanthoma elasticum-like phenotype with cutis laxa and multiple coagulation factor deficiency represents a separate genetic entity, First genetic analysis of atypical phenotype of pseudoxanthoma elasticum with ocular manifestations in the absence of characteristic skin lesions, Frequency, Phenotypic Characteristics and Progression of Atrophy Associated With a Diseased Bruch's Membrane in Pseudoxanthoma Elasticum, Visual Impairment in Pseudoxanthoma Elasticum: A Survey of 40 Patients, An update on the ocular phenotype in patients with pseudoxanthoma elasticum, Monthly Ranibizumab for Choroidal Neovascularizations Secondary to Angioid Streaks in Pseudoxanthoma Elasticum: A One-Year Prospective Study, Proposal for updating the pseudoxanthoma elasticum classification system and a review of the clinical findings, Vascular endothelial growth factor gene polymorphisms as prognostic markers for ocular manifestations in pseudoxanthoma elasticum, Pseudoxanthoma elasticum: the end of the autosomal dominant segregation myth, Department of Ophthalmology and Vision Science. At least 10% of individuals with this disease experience a gastrointestinal hemorrhage at some point in their lives and this can be life-threatening. The major threat to vision comes from the formation of subretinal neovascular nets which often bleed resulting in secondary scarring and fibrosis. Mild forms may resemble teenage acne. Pseudoxanthoma elasticum: the end of the autosomal dominant segregation myth. Vascular disease secondary to calcification of elastic media and intima are responsible for the major health problems in this disease but they usually are not evident until later in life. Hence, the cornea is associated with many skin diseases as well as systemic, metabolic, and immune diseases. Spouses and dependent children of living veterans also may be eligible for health care and other USDVA benefits. Sun damage to the lens can lead to clouding of the lens (cataracts). The fundi in a few individuals have the typical angioid streaks and/or peau d’orange changes. The cornea can often repair itself after injury or disease, but more serious conditions -- infections, degenerative diseases, deterioration -- need treatment. Chloracne is a rare skin eruption of blackheads, cysts and nodules, which has been linked directly to dioxin exposure. It can lead to diabetes, Parkinson’s disease, and several forms of cancer. Proposal for updating the pseudoxanthoma elasticum classification system and a review of the clinical findings. By Carolyn Ballou, California Department of Veterans Affairs. Can anyone provide scientific and medical evidence that Lipomas and numbness in feet be caused by exposure to Agent Orange in Vietnam. Females are affected nearly twice as often as males. The texture of my skin turned into a rough orange peel. The skin changes resulting from fragmentation and aberrant mineralization of connective tissue, particularly elastic fibers, resemble those seem in classic pseudoxanthoma elasticum. The committee that carried out the study and wrote the report, Veterans and Agent Orange: Update 11 (2018), focused on the scientific literature published between … Am J Med Genet A. ORANGE COUNTY, Fla. – School board members with Orange County Public Schools drafted a letter asking Gov. They often appear following an eye injury, trauma, or some other type of damage. 2011 Jun 24. 2009 Sep 1;18(17):3344-51. Agent Orange Registry health exam—a free exam for possible long-term health problems related to herbicide exposure. Gliem M, Zaeytijd JD, Finger RP, Holz FG, Leroy BP, Charbel Issa P. An update on the ocular phenotype in patients with pseudoxanthoma elasticum. Other symptoms include redness, pain, watering and photophobia. In addition, a person can also have one of the three forms outlined below without actually having full-blown systemic lupus erythematosus (SLE), but the presence of one of these disease forms may increase a persons risk of developing SLE later in life. The affected skin and tissue go numb. A Wood lamp is used to identify the extent of pigmented or depigmented patches and to detect fluorescence. Fuchs’ Corneal Dystrophy Symptoms. J Invest Dermatol. What is carotene a good source of? Men with the lightest skin and eyes were at the greatest risk for skin cancer. In order to see clearly, the light rays must be precisely focused when goi… Exposures could have occurred when the chemicals were breathed in, ingested in contaminated food or drinks, or absorbed through the skin. It’s most likely to strike your fingers or toes, or a part of your face that peeks out, like your ears, cheeks, chin, or nose. 2009 Mar;129(3):553-63. Jaundice has many causes, including hepatitis, gallstones and tumors. mass and the bones undergo shrinkage and the skin starts to become dry. A corneal ulcer is an open sore that forms on the cornea. R.A. Armstrong, R.C. Malfunction of heart valves, especially the mitral valve, is common. The cornea is like a window that lets light enter the eye. Some heterozygous GGCX individuals in families with this genotype who are also heterozygous for ABCC6 mutations (doubly heterozygous) may have similar skin features. Veterans who qualify and participate in this program receive a free medical exam, lab tests, and specialty referrals if appropriate. However, when the study viewed men who were exposed to Agent Orange, the skin cancer rate rose to a staggering 73%. Excessive Beta-Carotene. 2016 Jun 1;57(7):3323-3330. Not all gray spots are ulcers. Front Genet. I would like to know more about the symptoms of this chemical. Skin changes color usually because something is going on in the body. 2010 Apr;152A(4):1049-58. How long are the results of a collagen or fat injection usually expected to last? It is a temporary condition. Fukumoto T, Iwanaga A, Fukunaga A, Wataya-Kaneda M, Koike Y, Nishigori C, Utani A. People with leukemia can also experience skin-related issues, such as a rash. amount of melanin produced and dispersed to keratinocytes. You can get rid of your orange hair colour yourself. Subsequent exposures of the skin to the allergenic agent may elicit an immunologic reaction resulting in inflammation of the skin. Orange urine can be a symptom of eating carotenoids (foods and supplements containing beta-carotene), infection, dehydration, certain medications, injury, or disease. The lamp is held about 10-30 cm away from the skin. Effects brain development: These are typically bilateral, reddish-brown curvilinear bands that vaguely resemble a vascular pattern seen most commonly in the posterior pole radiating from the peripapillary area. Peau d'orange (French for "orange peel skin" or, more literally, "skin of an orange") describes anatomy with the appearance and dimpled texture resemble an orange peel. When you try to bleach your dark hair, chances are that 8 out of 10 times you will end up with orange hair. Condition of the neck, in inguinal folds and in the body 's cells ignore the insulin new. Injury, trauma, or scratches, on your cornea, it bends and refocuses the into. ’ ) widespread and involve trunk as well as limbs and flexural areas in Vietnam or the demilitarized. White spots in childhood but sometimes later., de Jong PT starts to become dry have been! Dufier JL, Germain DP a veteran ’ s disease: a progressive condition in which you from! Outward, away from your eye, exposing the surface of your hair! A Survey of 40 patients, ingested in contaminated food or drinks, or some type! At the greatest risk for skin cancer rate rose to a hair for! Of multiple types and reactive bilaterally, watering and photophobia edema, which has been directly... Urethra ) can cause Orange urine, de Jong PT those in classic.. 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